Human Genome Epidemiology (HuGE) Review Synopsis and Synthesis of Candidate-Gene Association Studies in Chronic Lymphocytic Leukemia: The CUMAGAS-CLL Information System
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چکیده
s from 719 unique publications were screened. 502 articles were excluded: • 23 articles were not in English. • 85 articles were not conducted in humans. • 99 articles were reviews/editorials. • 295 articles investigated irrelevant phenotypes or risk factors. Figure 1. Numbers of published articles retrieved for and excluded from an assessment of candidate-gene association studies of chronic lymphocytic leukemia, with specification of reasons, 1992–2009. CLL, chronic lymphocytic leukemia; CUMAGAS, Cumulative Meta-Analysis of Genetic Association Studies; HuGE, Human Genome Epidemiology; SLL, small lymphocytic lymphoma. 674 Zintzaras and Kitsios Am J Epidemiol 2009;170:671–678 Table 1. Meta-Analysis Results From Candidate-Gene Association Studies of Chronic Lymphocytic Leukemia, 1992–2009
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Synopsis and synthesis of candidate-gene association studies in chronic lymphocytic leukemia: the CUMAGAS-CLL information system.
A comprehensive and systematic assessment of the current status of candidate-gene association studies for chronic lymphocytic leukemia (CLL) was conducted. Data from 989 candidate-gene association studies (1992-2009) involving 905 distinct genetic variants were analyzed and cataloged in CUMAGAS-CLL, a Web-based information system which allows the retrieval and synthesis of data from candidate-g...
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